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B12 is present in many animal-based foods, including meat, eggs, and dairy

In the Phase 2 trial, participants on the 12 mg dose were still on a steep weight loss trajectory at 48 weeks, losing roughly 5-6 pounds per month even late in the treatment period

However, subtle differences exist based on their secondary receptor targets and clinical trial safety data

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

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